DFL23448

Overview

DFL23448 is a selective transient receptor potential melastatin-8 ( TRPM8 ) antagonist. DFL23448 shows IC 50 values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity ( IC 50 >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > TRP Channel

Product Information

• Catalog No.: HY-117372
• CAS No.: 1445753-16-1
• Molecular Formula: C12H10FN5OS
• Molecular Weight: 291.30
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source