UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC 50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT , respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease.
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