AZ3976

Overview

AZ3976 is a potent plasminogen activator inhibitor type 1 ( PAI-1 ) inhibitor with an IC 50 value of 26 μM in an enzymatic chromogenic assay. AZ3976 is active with an IC 50 of 16 μM in a plasma clot lysis assay. AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1 . AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1 . AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > PAI-1

Product Information

• Catalog No.: HY-117724
• CAS No.: 1418747-15-5
• Molecular Formula: C15H19N5O3
• Molecular Weight: 317.34
• Purity: 98.05%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.88 mM); Clear solution
• Availability: In-stock

Source

Original product source