DO34 analog

Overview

DO34 analog is a structural analog of DO34 ( HY-117771 ). DO34 is a selective DAGL inhibitor, with an IC 50 of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 blocks de novo 2-AG synthesis, and suppresses tonic CB 1 receptor activation. DO34 blocks depolarization-induced suppression of excitation and inhibition in the cerebellum and hippocampus. DO34 regulates feeding behavior and locomotor activity in mice. DO34 abolishes AM251-mediated enhancement of parallel fiber-evoked excitatory postsynaptic currents in cerebellar slices from MAGL global knockout mice. DO34 can be used for the research of energy balance disorder and neuroinflammation.

Application

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Product Information

• Catalog No.: HY-117771A
• CAS No.: 2098969-71-0
• Molecular Formula: C26H28F3N5O4
• Molecular Weight: 531.53
• Purity: 98.42%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Availability: In-stock

Source

Original product source