Go 7874 is a protein kinase C ( PKC ) inhibitor. Go 7874 mediated neuroprotection against LPS/IFNg-induced neuronal cell death in an immune-mediated neurotoxicity model, not through PKC activity. In contrast, the neuroprotective mechanism of Go 7874 involves inhibition of inducible nitric oxide synthase ( iNOS ) gene expression, followed by reduced nitric oxide (NO) production.
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