PPM-18

Overview

PPM-18 (NSC 73233) is a Vitamin K ( HY-B2172 ) analog. PPM-18 prevents LPS-induced IκBα degradation, thereby inhibiting NF-κB activation and nuclear translocation of NF-κB . PPM-18 inhibits LPS-induced nitrite production and iNOS expression. PPM-18 inhibits HDAC6 . PPM-18 induces ROS accumulation, activates AMPK , inhibits the mTORC1 and PI3K/AKT pathways, initiates Autophagy , and induces Apoptosis . PPM-18 suppresses seizures in zebrafish and mouse epilepsy models. PPM-18 prevents LPS-induced lethal toxicity and delayed hypotension. PPM-18 exhibits anticancer activity against leukemia and bladder cancer . PPM-18 can be used in research related to septic shock, bladder cancer and atherosclerosis.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Infection | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Bladder Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Epilepsy | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Disease Areas > Hypotension | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Others | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > IKK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-118160
• CAS No.: 65240-86-0
• Molecular Formula: C17H11NO3
• Molecular Weight: 277.27
• Purity: 99.17%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source