ADX71441

Overview

ADX71441 is an orally active, blood-brain barrier penetrant positive allosteric modulator of GABA B receptor . ADX71441 potentiates the activity of endogenous GABA at GABA B receptor, with an EC 50 of 96 nM. ADX71441 functionally inhibits adenosine transporters and 5-HT 2B receptor . ADX71441 produces anxiolytic-like, analgesic, muscle relaxant, hypothermic and overactive bladder inhibitory effects, reduces acute locomotor activity levels, decreases voluntary intake of alcohol and saccharin, attenuates stress-induced neuronal activation, and exhibits anti-hyperalgesic activity.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > GABA Receptor | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-118301
• CAS No.: 1207440-88-7
• Molecular Formula: C19H15ClF2N4O4
• Molecular Weight: 436.80
• Purity: 98.63%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source