4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoic acid

Overview

4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoic acid is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.

Application

Products > ADC Linker, ADC Payload > Site Specific Linkers | Products > ADC Linker, ADC Payload > Site Specific Linkers > Sulfone-PEG-Acid

Product Information

• Catalog No.: BP-22307
• CAS No.: 124243-00-1
• Molecular Formula: C25H24O7S2
• Molecular Weight: 500.6
• Purity: 98%
• Storage: -20°C
• Availability: In Stock

Source

Original product source