UBP141 is a GluN2C/2D (NR2C/2D) -preferring receptor antagonist, with K d s of 2.8, 4.2, 14.2, and 19.3 μM for NMDA receptor subtypes: GluN2C, 2D, 2A, and 2B, respectively. UBP141 can induce potent motor impairment in WT mice.
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