HI-346 is a non-nucleoside reverse transcriptase inhibitor ( NNRTI ) for HIV-1 with an IC 50 value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC 50 value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research.
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