L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a K i of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes.
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