KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an K i value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1 , A2A and A2B receptors , respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors . KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma.
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