CM-414

Overview

CM-414 is a brain-penetrant phosphodiesterase 5 ( PDE5 ) and HDAC inhibitor with IC50s of 60 nM, 91 nM, 310 nM, 322 nM and 490 nM for PDE5 , HDAC6 , HDAC1 , HDAC3 and HDAC2 , respectively. CM-414 diminishes brain Aβ and tau phosphorylation (pTau) level in Tg2576 mice. CM-414 can be used for the study of Alzheimer's disease (AD).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > Amyloid-β | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-119316
• CAS No.: 2007971-51-7
• Molecular Formula: C23H29N5O4
• Molecular Weight: 439.52
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source