Salacinol, compound found in Salacia reticulata , is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase ( IC 50 = 3.2 μg/mL, K i = 0.31 μg/mL), sucrase ( IC 50 = 0.84 μg/mL, K i = 0.32 μg/mL), and isomaltase ( IC 50 = 0.59 μg/mL, K i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase . Salacinol can be used for the research of diabetes mellitus.
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