(rel)-AR234960

Overview

(rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS . (rel)-AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway, inducing the expression of connective tissue growth factor ( CTGF ) and its downstream collagen subtype genes (such as COL1A1, COL3A1). (rel)-AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. (rel)-AR234960's in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor . (rel)-AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Depression | Products > Disease Areas > Pain | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-120006A
• CAS No.: 1408311-94-3
• Molecular Formula: C27H30FN5O5S
• Molecular Weight: 555.62
• Purity: 98.95%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (4.50 mM); Clear solution
• Availability: In-stock

Source

Original product source