GK470

Overview

GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 ( GIVA cPLA 2 ) with an IC 50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC 50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate ( HY-14519 ) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE 2 levels.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Phospholipase

Product Information

• Catalog No.: HY-120050
• CAS No.: 1621517-53-0
• Molecular Formula: C21H27NO4S
• Molecular Weight: 389.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source