Erlotinib-d 6 hydrochloride

Overview

Erlotinib-d 6 hydrochloride (CP-358774-d 6 hydrochloride) is the deuterated-labeled Erlotinib Hydrochloride ( HY-12008 ). Erlotinib (CP-358774) Hydrochloride is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib Hydrochloride also acts as a substrate and inhibitor of OATP2B1 , with an IC 50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib Hydrochloride blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib Hydrochloride inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2 , GSK-3β and β-catenin signaling pathways, as well as the deposition of fibronectin, α-SMA, collagen and renal injury markers. Erlotinib Hydrochloride is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib Hydrochloride can be used in research related to non-small cell lung cancer , gastric cancer , papillary renal cell carcinoma, EGFR inhibitor resistance and renal fibrosis.

Application

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Product Information

• Catalog No.: HY-12008S
• CAS No.: 1189953-78-3
• Molecular Formula: C22H18D6ClN3O4
• Molecular Weight: 435.93
• Purity: 98.13%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source