D-520

Overview

D-520 is a potent and brain-penetrant dopamine D2/D3 agonist (D2 EC 50 = 4.73 nM, K i = 41.8 nM; D3 EC 50 = 2.18 nM, K i = 0.35 nM). D-520 inhibits the formation of Aβ aggregates in vitro and promotes the disaggregation of both alpha-synuclein (α-syn) and Aβ aggregates. D-520 exhibits efficacious activity in animal models of Parkinson’s disease (PD). D-520 can be used for PD and PD with dementia (PDD) research [1][2] .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Receptor | Products > Signaling Pathways > α-synuclein | Products > Signaling Pathways > Amyloid-β

Product Information

• Catalog No.: HY-120156
• CAS No.: 1619269-47-4
• Molecular Formula: C31H39N3O3
• Molecular Weight: 501.66
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source