GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis .GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia.
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