17(R)-HDHA (17(R)-HDoHE) is a pro-resolving mediator (SPM). 17(R)-HDHA enhances the differentiation of B cells toward the CD27 (+) CD38 (+) antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells. 17(R)-HDHA does not affect cell proliferation and is non-toxic to cells.
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