SLM6031434

Overview

SLM6031434 is a highly selective sphingosine kinase 2 ( SphK2 ) inhibitor with an IC 50 value of 0.4 μM for SphK2 . SLM6031434 exerts anti-fibrotic effects by increasing sphingosine accumulation and Smad7 expression. SLM6031434 demonstrates effective anti-fibrotic efficacy in a unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis mouse model. SLM6031434 can be used for the study of proteinuric kidney diseases or chronic kidney disease (CKD).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > SphK

Product Information

• Catalog No.: HY-120268
• CAS No.: 1897379-33-7
• Molecular Formula: C22H30F3N5O2
• Molecular Weight: 453.50
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source