Genz-669178

Overview

Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC 50 of 0.015-0.05 μM in Plasmodium spp. . Genz-669178 inhibits P. berghei , P. falciparum strains 3D7 and Dd2 with IC 50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei -infected mice with ED 50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Dihydroorotate Dehydrogenase | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-120462
• CAS No.: 1254834-91-7
• Molecular Formula: C17H14N4OS
• Molecular Weight: 322.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source