AM-6226 is a potent and orally active G protein coupled receptor 40 ( GPR40 ) full agonist with an EC 50 of 0.12 μM. AM-6226 can activate the GPR40 receptors on pancreatic β cells and enteroendocrine L cells, promote insulin secretion in a glucose-dependent manner and also increase the release of incretin hormones ( GLP-1 , GIP), thereby avoiding the risk of hypoglycemia. AM-6226 can be used for the research of metabolic disease , such as diabetes.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Free Fatty Acid Receptor
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