(S)-TROX-1

Overview

(S)-TROX-1 is the S-enantiomer of TROX-1 ( HY-120751 ). TROX-1 is a selective, orally active and brain-penetrant N-type calcium channel ( Cav2.2 ) inhibitor with an IC 50 value of 0.11 μM. TROX-1 exerts state-dependent and use-dependent inhibition, preferentially targets open/inactivated channels, blocks depolarization-associated calcium influx, and fully blocks calcium influx in rat dorsal root ganglion neurons. TROX-1 reverses inflammatory-induced hyperalgesia, nerve injury-induced allodynia. TROX-1 can be used for the research of pain.

Application

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Product Information

• Catalog No.: HY-120751A
• CAS No.: 2751591-42-9
• Molecular Formula: C22H16ClFN6O
• Molecular Weight: 434.85
• Purity: 99.52%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source