Endosidin-2

Overview

Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70 . Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2 ) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting).

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Others | Products > Signaling Pathways > Exosomes

Product Information

• Catalog No.: HY-120821
• CAS No.: 1839524-44-5
• Molecular Formula: C15H12FIN2O3
• Molecular Weight: 414.17
• Purity: 99.17%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source