UNC9995

Overview

UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2 . UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2 - NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2 / β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK / STAT3 . UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Depression | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Dopamine Receptor

Product Information

• Catalog No.: HY-120920
• CAS No.: 1354030-52-6
• Molecular Formula: C20H21Cl2N3OS
• Molecular Weight: 422.37
• Purity: 99.93%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (2.96 mM); Clear solution
• Availability: In-stock

Source

Original product source