MMP408

Overview

MMP408 is a selective and orally effective inhibitor of MMP-12 with IC 50 values for human, mouse and rat MMP-12 of 2 nM, 160 nM and 3 μM respectively. MMP408 exhibits IC 50 value for human MMP-13 of 120 nM, and its activity against other MMPs is weak. MMP408 can alleviate inflammation, fibrosis and tissue remodeling by inhibiting MMP-12 . MMP408 can be used in the research of chronic obstructive pulmonary disease and chronic sinusitis with nasal polyps.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Lung Fibrosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MMP

Product Information

• Catalog No.: HY-12093
• CAS No.: 1025716-81-7
• Molecular Formula: C19H20N2O7S
• Molecular Weight: 420.44
• Purity: 99.04%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (2.97 mM); Clear solution
• Availability: In-stock

Source

Original product source