Mepazine acetate

Overview

Mepazine acetate (Pecazine acetate) is a drug that has the activity to inhibit the protease activity of MALT1 . Mepazine acetate is often used to study the role of MALT1 in biology. Treatment of mouse bone marrow precursor cells with mepazine acetate strongly inhibited RANK ligand (RANKL)-induced osteoclast formation. Mepazine acetate also inhibited the expression of multiple osteoclast markers such as TRAP, feline hepsin K, and calcitonin . The protective effect of mepazine acetate was not affected by MALT1 deficiency. The mechanism of action of mepazine acetate may involve MALT1-independent mechanisms, and this aspect needs to be considered in future studies.

Application

Products | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Others | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MALT1

Product Information

• Catalog No.: HY-121282B
• CAS No.: 24360-97-2
• Molecular Formula: C21H26N2O2S
• Molecular Weight: 370.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source