Flutonidine (ST-600) is a Clonidine ( HY-12721 ) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1 , α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors . Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides.
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