Vofopitant dihydrochloride

Overview

Vofopitant dihydrochloride (GR 205171A) is a blood-brain barrier-permeable NK1 receptor inhibitor with a pKi of 9.02 in mice. Vofopitant dihydrochloride blocks vomiting-related responses and inhibits pseudoptyalism. Vofopitant dihydrochloride exerts anxiolytic effects, regulates 5-HT receptor function and increases central 5-HT release. Vofopitant dihydrochloride improves hyperarousal symptoms of post-traumatic stress disorder. Vofopitant dihydrochloride can be used in research related to depression, anxiety, vomiting and postoperative nausea and vomiting.

Application

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Product Information

• Catalog No.: HY-12143
• CAS No.: 168266-51-1
• Molecular Formula: C21H25Cl2F3N6O
• Molecular Weight: 505.36
• Purity: 99.56%
• Storage: 4°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution
• Availability: In-stock

Source

Original product source