PPARδ agonist 10 (compound 7) is an orally active, selective, and partial agonist of PPARδ , with EC 50 values of 0.053 μM and 0.30 µM for hPPARδ(LBD)-GAL4 and mPPARδ , respectively. PPARδ agonist 10 is a partial PPARδ agonist in transactivation assay but a full agonist on free fatty acids (FFA) oxidation in muscle cells both in vitro and in vivo. PPARδ agonist 10 can be used for dyslipidemia research.
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