ML138

Overview

ML138 is a blood-brain barrier-permeable κ-opioid receptor ( KOR ) agonist, with an EC 50 value of 0.87 μM and a human K i value of 2.4 nM for human receptors; it exhibits high selectivity for KOR over μ, δ and other receptors. ML138 activates β-arrestin ( beta-arrestin )-mediated signaling pathways, stimulates G protein coupling, and activates the downstream extracellular regulated protein kinase 1/2 ( ERK1/2 ) mitogen-activated protein kinase ( MAP kinase ) signaling pathway. ML138 is applicable to research related to addictive behaviors.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Behavioral Addiction | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Opioid Receptor | Products > Signaling Pathways > Arrestin | Products > Signaling Pathways > ERK | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-121800
• CAS No.: 1355243-24-1
• Molecular Formula: C19H14Cl2N4OS
• Molecular Weight: 417.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source