Sulfiram

Overview

Sulfiram is a very weak aldehyde dehydrogenase ( ALDH ) inhibitor, with an IC 50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram ( HY-B0240 ), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein ( APP ), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Infection | Products > Signaling Pathways > Aldehyde Dehydrogenase (ALDH) | Products > Signaling Pathways > Drug Intermediate | Products > Signaling Pathways > Amyloid-β

Product Information

• Catalog No.: HY-121817
• CAS No.: 95-05-6
• Molecular Formula: C10H20N2S3
• Molecular Weight: 264.47
• Purity: 96.35%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source