DP-b99

Overview

DP-b99 is a blood-brain barrier-permeable inhibitor of CYP2C9 and MMP-9 , with a K i value of 4.655 μM against CYP2C9 . DP-b99 inhibits CYP2C9 via apparent non-competitive inhibition, mainly chelates pathological Zn 2+ in the membrane environment, attenuates the elevation of intracellular Zn 2+ and Ca 2+ levels, delays seizure onset and reduces seizure severity, and also prevents MMP-9-dependent dendritic spine remodeling, β-dystroglycan cleavage and gelatinase activity. DP-b99 can be used in the research of acute ischemic stroke, epileptogenesis and stroke.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > MMP | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-121872
• CAS No.: 222315-88-0
• Molecular Formula: C42H64N2O12
• Molecular Weight: 788.96
• Purity: 95.0%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution
• Availability: In-stock

Source

Original product source