FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase ( iNOS ) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC 50 of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides ( HY-D1056 )-induced inflammatory diseases in rats model.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NO Synthase
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