JHU-083

Overview

JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b + cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Glutaminase

Product Information

• Catalog No.: HY-122218
• CAS No.: 1998725-11-3
• Molecular Formula: C14H24N4O4
• Molecular Weight: 312.36
• Purity: 99.38%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution
• Availability: In-stock

Source

Original product source