LY487379

Overview

LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ 35 S]GTPγS binding with EC 50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research.

Application

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Product Information

• Catalog No.: HY-122255
• CAS No.: 353231-17-1
• Molecular Formula: C21H19F3N2O4S
• Molecular Weight: 452.45
• Purity: 98.92%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 10 mg/mL (22.10 mM); Clear solution
• Availability: In-stock

Source

Original product source