MT-802

Overview

MT-802 is a BTK PROTAC degrader. MT-802 degrades wild-type BTK ( DC 50 = 14.6 nM) and BTK mutants including E41K, C481S ( DC 50 = 14.9 nM), C481R, C481Y, C481T, C481F, L528W, and inhibits their Y223 phosphorylation. BI-4732 can be used for the study of Ibrutinib ( HY-10997 )-resistant chronic lymphocytic leukemia (CLL). (Pink: BTK ligand ( HY-150885 ), Blue: CRBN Ligand ( HY-14658 ), Black: Linker ( HY-141371 ), E3 ligase ligand-linker conjugate (HY-176340)). (Pink: Btk ligand ( HY-150885 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-141371 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Btk

Product Information

• Catalog No.: HY-122562
• CAS No.: 2231744-29-7
• Molecular Formula: C41H41N9O8
• Molecular Weight: 787.82
• Purity: 98.35%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution
• Availability: In-stock

Source

Original product source