TL13-12

Overview

TL13-12 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC 50 value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A , FER , PTK2 , and RPS6KA1 with IC 50 values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 ( HY-10192 ) and the Cereblon ligand of Pomalidomide ( HY-10984 ). (Pink: Anaplastic lymphoma kinase (ALK) ligand ( HY-184540 ); Blue: Cereblon ligand ( HY-131717 ); Black: linker ( HY-130485 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK)

Product Information

• Catalog No.: HY-122582
• CAS No.: 2229037-04-9
• Molecular Formula: C45H53ClN10O10S
• Molecular Weight: 961.48
• Purity: 98.16%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source