T-448 free base is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) , with an IC 50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Histone Demethylase
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