Leucrose (5-O-α-D-Glucopyranosyl-D-fructose) is an orally active Sucrose ( HY-B1779 ) isomer naturally found in pollen and honey. Leucrose promotes phosphorylation of JAK1 and STAT6 , reduces pro-inflammatory mediators and cytokinesas ( TNFα , and IL-1β ), increases M2 macrophage polarization and suppresses DSS ( HY-116282C )-induced colitis. Leucrose suppresses hepatic triglyceride accumulation, improves fasting blood glucose levels, and regulates hepatic lipogenesis and fatty acid β-oxidation in high-fat diet-induced obese mice. Leucrose is slowly hydrolyzed into glucose and fructose by α-glucosidase and acts as as a sugar substitute in diet.
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