JY-XHe-053 is a potent and selective agonist of GABAA receptors containing the α5 subunit ( K i s of 22.0 nM, 12.3 nM, 34.9 nM, 0.7 nM for α1, α2, α3, α5, respectively). JY-XHe-053 lacks significant anti-anxiety activity, despite its efficacy at α2- and α3-GABAA receptors.
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