PD 131628 is an antimicrobial agent and active PD 131112 metabolite. PD 131628 is two- to four-fold more active than Ciprofloxacin ( HY-B0356 ), inhibiting all strains of Staphylococcus aureus and Streptococcus pneumoniae . PD 131628 is very active against Neisseria spp., Haemophilus influenzae and Moraxella catarrhalis , with MIC 90 s ranging from 0.004 to 0.008 mg/L.
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