JNJ10191584

Overview

JNJ10191584 (VUF6002) is an orally active and selective histamine H 4 receptor antagonist with a K i value of 26 nM. JNJ10191584 shows 540-fold selectivity to H 4 receptor over H 3 receptor with a K i value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC 50 values of 530 nM and 138 nM, respectively.

Application

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Product Information

• Catalog No.: HY-123532
• CAS No.: 73903-17-0
• Molecular Formula: C13H15ClN4O
• Molecular Weight: 278.74
• Purity: 99.90%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 5 mg/mL (17.94 mM); Clear solution
• Availability: In-stock

Source

Original product source