Siponimod

Overview

Siponimod (BAF-312) is an orally active, blood-brain barrier penetrant dual agonist of S1P1 / S1P5 , with EC 50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis.

Application

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Product Information

• Catalog No.: HY-12355
• CAS No.: 1230487-00-9
• Molecular Formula: C29H35F3N2O3
• Molecular Weight: 516.60
• Purity: 99.95%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
• Availability: In-stock

Source

Original product source