MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase) -targeting antimalarial agent, with an IC 50 of 44 nM for Pf IspD ( P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC 50 of 250 nM.
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