MIP-1095 (RPS-001) is a PSMA inhibitor with a K i value of 0.24 nM. MIP-1095 binds to PSMA with high affinity and can be internalized into PSMA -expressing cancer cells. When radiolabeled with 123 I, 124 I or 131 I, MIP-1095 enables SPECT/CT imaging, PET/CT imaging or targeted radiation delivery, respectively. 131 I-MIP-1095 can alter serum PSA levels and relieve bone pain. MIP-1095 can be used in research related to metastatic castration-resistant prostate cancer .
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