THAL-SNS-032

Overview

THAL-SNS-032 is a selective CDK9 PROTAC degrader. THAL-SNS-032 recruits CRBN to form a ternary complex with CDK9 , thereby triggering ubiquitination and proteasomal degradation of CDK9 . THAL-SNS-032 also induces the degradation of CDK1 , CDK2 and CDK7 . THAL-SNS-032 elevates pH2AX levels, reduces MCL1s expression, and activates caspase-3 . THAL-SNS-032 induces cancer cell apoptosis , regulates transcription, and inhibits the replication of human cytomegalovirus ( CMV ) and SARS-CoV-2 . THAL-SNS-032 can be used in research related to breast cancer , leukemia, cytomegalovirus infection and SARS-CoV-2 infection . (Pink: CDK9 ligand ( HY-10008 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-W015088 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Viral Infection | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Cytomegalovirus Infection | Products > Disease Areas > SARS-CoV-2 Infection | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SARS-CoV | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > CMV

Product Information

• Catalog No.: HY-123937
• CAS No.: 2139287-33-3
• Molecular Formula: C40H52N8O10S2
• Molecular Weight: 869.02
• Purity: 97.11%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution
• Availability: In-stock

Source

Original product source