Raphin1

Overview

Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B) . Raphin1 binds strongly to the R15B-PP1c holophosphatase ( K d =33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Phosphatase

Product Information

• Catalog No.: HY-123960
• CAS No.: 2022961-17-5
• Molecular Formula: C8H8Cl2N4
• Molecular Weight: 231.08
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (9.00 mM); Clear solution
• Availability: In-stock

Source

Original product source