ZK159222

Overview

ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Research Areas > Endocrinology | Products > Signaling Pathways > VD/VDR

Product Information

• Catalog No.: HY-12397
• CAS No.: 156965-15-0
• Molecular Formula: C32H48O5
• Molecular Weight: 512.72
• Purity: 99.23%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution
• Availability: In-stock

Source

Original product source